64Cu-Labeled multifunctional dendrimers for targeted tumor PET imaging
نویسندگان
چکیده
منابع مشابه
Radionuclide (131)I-labeled multifunctional dendrimers for targeted SPECT imaging and radiotherapy of tumors.
We report the synthesis, characterization, and utilization of radioactive (131)I-labeled multifunctional dendrimers for targeted single-photon emission computed tomography (SPECT) imaging and radiotherapy of tumors. In this study, amine-terminated poly(amidoamine) dendrimers of generation 5 (G5·NH2) were sequentially modified with 3-(4'-hydroxyphenyl)propionic acid-OSu (HPAO) and folic acid (FA...
متن کاملMultifunctional MIL-S─CUR@FC nanoparticles: a targeted theranostic agent for magnetic resonance imaging and tumor targeted delivery of curcumin
Introduction: Noninvasive magnetic resonance imaging (MRI) and targeted drug delivery systems, usually referred to as theranostic agents, are being developed to enable detection, site-specific treatment, and long-term monitoring. Materials and Methods: To elucidate the effects of coating on cellular uptake and biodistribution of n...
متن کامل64Cu-Labeled Inhibitors of Prostate-Specific Membrane Antigen for PET Imaging of Prostate Cancer
Prostate-specific membrane antigen (PSMA) is a well-recognized target for identification and therapy of a variety of cancers. Here we report five (64)Cu-labeled inhibitors of PSMA, [(64)Cu]3-7, which are based on the lysine-glutamate urea scaffold and utilize a variety of macrocyclic chelators, namely NOTA(3), PCTA(4), Oxo-DO3A(5), CB-TE2A(6), and DOTA(7), in an effort to determine which provid...
متن کامل64Cu-Labeled LyP-1-Dendrimer for PET-CT Imaging of Atherosclerotic Plaque
The ability to detect and quantify macrophage accumulation can provide important diagnostic and prognostic information for atherosclerotic plaque. We have previously shown that LyP-1, a cyclic 9-amino acid peptide, binds to p32 proteins on activated macrophages, facilitating the visualization of atherosclerotic plaque with PET. Yet, the in vivo plaque accumulation of monomeric [(18)F]FBA-LyP-1 ...
متن کاملMultifunctional Nanostructures for Tumor-Targeted Molecular Imaging and Photodynamic Therapy.
A multifunctional ICG-FA-PPD nanostructure is constructed by a facile self-assembly method through the negatively charged indocyanine green (ICG)- and positively charged folic acid-modified PEI-PEG-gadoteric acid (FA-PPD). The resulting ICG-FA-PPD is not only able to be used for targeting tumors, magnetic resonance imaging (MRI), and near-infrared imaging, but, more importantly, it enables phot...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanoscale
سال: 2018
ISSN: 2040-3364,2040-3372
DOI: 10.1039/c7nr09269e